PSV Eindhoven played out a thrilling match at VVV-Venlo that ended in a 3-3 draw as the home side finished with 10 men
PSV struck the first blow when Ola Toivonen netted in the 11th minute before Dries Mertens doubled their advantage at De Koel.
But Ferry de Regt reduced VVV-Venlo's deficit early in the second half before Nwofor Uche restored parity. And on 54 minutes Maya Yoshida completed a terrific turnaround.
However, Wilfred Bouma scored with 14 minutes left on the clock to make it 3-3, while Marcel Meeuwis was handed his marching orders in the final moments.
Feyenoord maintained their unbeaten start to the campaign after they came from a goal down to record a 3-1 scalp of NAC Breda.
Robbert Schilder broke the deadlock in the seventh minute only for Otman Bakkal to equalise before the half-time interval.
Feyenoord upped their game in the second period as a goal from Karim El Ahmadi and a late penalty from John Guidetti wrapped up their away triumph.
FC Utrecht emerged as 3-2 victors in their meeting with Excelsior, who were reduced to ten men early in the second half.
Jason Oost put Excelsior in front on five minutes only for goals from Nana Asare and Ismo Vostermans to turn the game on its head.
Samuel Scheimann then received a second yellow card to toughen Excelsior's task before Asare extended FC Utrecht's lead. Joost Broerse's 69th minute goal proved only a consolation.
Heerenveen eased to a 3-0 victory over FC Groningen at Abe Lenstra Stadion with Bas Dost, Oussama Assaidi and Filip Djuricic all on target.
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Ajax took over at the top of the Eredivisie table after edging out Heracles Almelo 3-2 while erstwhile pacesetters FC Twente lost their 100% start.
Defending champions Ajax fell behind after 30 minutes when Willy Overtoom netted but the visitors hit back with a brace from Siem De Jong and an 80th-minute strike from Miralem Sulejmani to go 3-1 ahead.
The Amsterdammers suffered a scare late on when Glynor Plet pulled a goal back in the 88th minute before the away side were reduced to ten men when Lorenzo Ebecilio got his marching orders in injury time, but Frank De Boer's men held on for the victory.
They are now a point clear at the summit, with FC Twente slipping to third after losing 2-1 at Roda JC..
The 2010 Dutch title winners took the lead through Marc Janko in the 35th minute but that advantage lasted just 60 seconds before Roda drew level through Ruud Vormer.
The home side would then go on to take the spoils when Mitchell Donald struck two minutes after half-time.
AZ Alkmaar moved up to second place - leaving the last three Dutch champions occupying the top three spots - after brushing aside Vitesse Arnhem 4-0 thanks to a devastating first-half display.
All four of the 2009 Eredivisie champions' goals arrived during a 23-minute spell prior to half-time, with Pontus Wernbloom (two) , Roy Beerens and Rasmus Elm, from the penalty spot, finding the back of the net.
There was no way back for Vitesse after that and they finished the match with ten men when Wilfried Bony was sent off with 20 minutes remaining.
RKC Waalwijk moved into the top four thanks to Rick Ten Voorde's 33rd-minute goal as they beat ADO Den Haag 1-0, while De Graafschap also beat NEC Nijmegen 1-0 courtesy of a 24th-minute Soufian El Hassnaoui goal.
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